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Extra copies of genes may exacerbate social problems among autistic

By Staff Writer

A gene found in neuron synapses that allows for the communication of inhibitory and excitatory signals between cells may increase the severity of social dysfunction that often accompanies autism spectrum disorders, according to a recent study published in the journal Proceeding of the National Academy of Sciences.

The researchers said they believe that individuals with one or more copies of the gene glutamate receptor interacting protein 1 (GRIP1) experience progressively worse social difficulties.

To support their theory, investigators provided mice with the option to either socialize with other rodents or interact with an inanimate object. The findings indicated that the laboratory rodents with one or more copies of GRIP1 chose to be social with others of their species two times more often than mice who didn't have the gene.

Furthermore, the researchers evaluated human autistic siblings. Results showed that although both children has similar levels of developmental disability, those who had two copies of GRIP1 received lower social ability scores than their brothers or sisters with one or no gene mutations.

Many kids with learning impairments find it difficult to relate to their peers. Boarding schools may provide a nurturing environment for the education of autistic children.

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